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KMID : 1031120140040010014
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Journal of Epilepsy Research
2014 Volume.4 No. 1 p.14 ~ p.17
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Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study
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Park Kyung-Il
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Abstract
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Background and Purpose: To explore the clinical feasibility of plasma brain-type natriuretic peptide (proBNP) level to differentiate the two major causes of transient unconsciousness, seizure and vasovagal syncope (VVS) in adult patients.
Methods: ProBNP levels were evaluated within 24 hours following attack in patients who had experienced a transient episode of unconsciousness. For confirmatory diagnosis, clinical history was reviewed thoroughly and several work-ups including electroencephalography and cerebral imaging and tilt-table test, were performed in cases of putative VVS, as a part of routine clinical approaches.
Results: According to various relevant evaluations, 15 patients were diagnosed as seizure (age, 40.3±13.8 years) and 12 patients were VVS (age, 38.1±17.1 years). Plasma concentrations of pro-BNP were not different between two groups (p=0.714). Median level was 34.3 pg/mL (interquartile range: 12.9?91.1) in post-seizure group and 32.3 pg/mL (interquartile range 8.9?77.4) in post-VVS group. Additionally, it was not correlated with the sampling times within 24 hours after the episodes.
Conclusions: The plasma level of pro-BNP has a limited clinical value in differentiating seizure and vasovagal syncope in adults. However, the more validated results with a large population should be sought in the future studies to confirm its value.
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KEYWORD
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Brain-type natriuretic peptide, Seizure, Syncope
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